Endocrinologic and Psychologic Evaluation of 21-Hydroxylase Deficiency Carriers and Matched Normal Subjects: Evidence for Physical and/or Psychologic Vulnerability to Stress

Endocrinologic and psychologic evaluation of 21-hydroxylase deficiency carriers and matched normal subjects: evidence for physical and/or psychologic vulnerability to stress.

Carriers of congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency demonstrate increased secretion of cortisol precursors after ACTH stimulation, suggestive of impaired cortisol production and compensatory increases in hypothalamic CRH secretion. Because both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of...

Psychological vulnerability to stress in carriers of congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

OBJECTIVE Carriers of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) demonstrate increased secretion of cortisol precursors following ACTH stimulation, suggestive of impaired cortisol production and compensatory increases in hypothalamic corticotropin-releasing hormone (CRH) secretion. Both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecre...

Physical and Psychologic Effects of Methamphetamine

84 Dr Shoptaw is a Professor in the Department of Family Medicine at the University of California, Los Angeles. Methamphetamine is a long-acting stimulant. It goes by various street names, including crystal, tina, speed, and crank. It can be injected, insufflated (snorted), smoked (eg, by heating on aluminum foil and inhaling the vapor through a pen or straw), taken orally, or taken via “booty-...

The prooxidant state and psychologic stress.

We have read with interest the work by Lesgards et al. (1) on the effect of different lifestyle factors on their test system, which measures the resistance of red blood cells to an oxidative challenge. Their study showed that psychologic stress is a major factor influencing antioxidant status. This finding encouraged us to share our experiences of a earlier study that resulted in similar conclu...

Physical and Psychologic Factors in Glue Sniffing.